Otto-William (died 1026) was duke of Burgundy between 1002 and 1004. Otto-William was son of Otto-Henry, the Great, who he succeeded in the duchy at a young age.

Determined to be sovereign ruler of his own lands, Otto-William revolted against Henry II, Holy Roman Emperor in 1016. Burgundy was annexed to the crown of France by king Robert II in 1004, and after this date, Otto-William was nominal count of Burgundy. Later Robert gave the duchy to his heir, future king Henry I of France.

He married Ermentrude of Reims, daughter of Count Renaud of Reims. Their children were:
1. Agnes of Burgundy, married (1) William V of Aquitaine; (2) Geoffrey II of Anjou
2. Geberge of Burgundy, married Guilhem II of Provence
3. Matilda of Burgundy, married Landri of Nevers
4. Renaud I, Count of Burgundy