Bohemund II Guiscard (1108-1131) was the Prince of Antioch between 1111 and 1131 and Prince of Taranto from 1111 to 1128. He was the son of the founder of the principalities, Bohemund I, by his marriage with princess Constance of France (daughter of Philip I). During his minority, Antioch was ruled by three regents: his cousin Tancred (1111-1112), Roger of Salerno (1112-1119) and Baldwin II of Jerusalem (1119-1126).

In October 1126 he came from Apulia to Antioch to assume the control of the principality from the hands of the King of Jerusalem. In the following year, Bohemund II married Alice, the younger daughter of Baldwin, and joined his new father-in-law in an attack against Damascus. The next years of his rule were marked by conflicts with Joscelin I of Edessa and skirmishes in the northern border. Finally in February 1131, Bohemund was lured into an ambush and his army was defeated by a Danishmendid army. Bohemund died in the struggle, and his blond head was embalmed, placed in a silver box, and sent as a gift to the caliph. From his marriage to Alice, only one daughter, Constance of Antioch survived.